Every issue is self contained and no prior reading is necessary to understand the content of each issue. It's generally meant to provide context and backstory as well as world building.
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Issue 1 focuses on Nevya Kralovna, a porn actress. Because she is treated badly on the set of her latest film she quits. In the locker room she is approached by Dr. Hugo Schneider who offers her 500 000 dollars if she partakes in an experient. She refuses and Schneider gives her his card in case she changes her mind. At home, she learns that her family has run out of money and her brother, who was supposed to get some work, has apparently run out on the family. So Nevya decides to take Schneider up on his offer.
The procedude is quick and painless and she is released back into the wild with her money. On her way home she is followed and when she arrives at her family's place to show them the money, they are being robbed. Nevya however quickly takes out a gun and shoots the robber, realizing too late that the crook is her brother. She tells her mother to take the money and use it to pay the bills only and not give her a lawyer, she will turn herself in.
Nevya is sentenced to cryo prison for seven years, a humane senence because she turned herself in. After two years, however, Chrome breaks her out as her body has undergone changes due to Schneiders experiment. Schneider reveals that he staged the break in and that the judge was in on the scheme, knowing that it would kill her unborn child. Her family has been deported and the issue closes with her eyes going blank as Schneider wipes her memory forever.